Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents

Arylimidamide (AIA) compounds containing two pyridylimidamide terminal groups (bis-AIAs) possess outstanding in vitro antileishmanial activity, and the frontrunner bis-AIA DB766 (2,5-bis[2-(2-isopropoxy)-4-(2-pyridylimino)aminophenyl]furan) is active in visceral leishmaniasis models when given orall...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Zhu, Xiaohua, Farahat, Abdelbasset A., Mattamana, Meena, Joice, April, Pandharkar, Trupti, Holt, Elizabeth, Banerjee, Moloy, Gragg, Jamie L., Hu, Laixing, Kumar, Arvind, Yang, Sihyung, Wang, Michael Zhuo, Boykin, David W., Werbovetz, Karl A.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Science Ltd 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841789/
https://ncbi.nlm.nih.gov/pubmed/27048943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.082
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