Time-resolved multimodal analysis of Src Homology 2 (SH2) domain binding in signaling by receptor tyrosine kinases

While the affinities and specificities of SH2 domain-phosphotyrosine interactions have been well characterized, spatio-temporal changes in phosphosite availability in response to signals, and their impact on recruitment of SH2-containing proteins in vivo, are not well understood. To address this iss...

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Bibliographic Details
Published in:eLife
Main Authors: Jadwin, Joshua A, Oh, Dongmyung, Curran, Timothy G, Ogiue-Ikeda, Mari, Jia, Lin, White, Forest M, Machida, Kazuya, Yu, Ji, Mayer, Bruce J
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2016
Subjects:
Biochemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841779/
https://ncbi.nlm.nih.gov/pubmed/27071344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11835
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