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Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane
Receptor tyrosine kinases (RTKs) control a host of biological functions by phosphorylating tyrosine residues of intracellular proteins upon extracellular ligand binding. The phosphotyrosines (p-Tyr) then recruit a subset of ∼100 Src homology 2 (SH2) domain-containing proteins to the cell membrane. T...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435163/ https://ncbi.nlm.nih.gov/pubmed/22886086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203397109 |
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