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A phage display selection of engrailed homeodomain mutants and the importance of residue Q50

Mutants of engrailed homeodomain (HD) that retain DNA-binding activity were isolated using a phage display selection. This selection was used to enrich for active DNA-binding clones from a complex library consisting of over a billion members. A more focused library of mutant homeodomains consisting...

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Detalhes bibliográficos
Main Authors: Simon, Matthew D., Sato, Ken, Weiss, Gregory A., Shokat, Kevan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC484177/
https://ncbi.nlm.nih.gov/pubmed/15247345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh690
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