Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, yet disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD. Since alpha-synuclein (α-Syn) aggregation is a major hallmark...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Tatenhorst, Lars, Eckermann, Katrin, Dambeck, Vivian, Fonseca-Ornelas, Luis, Walle, Hagen, Lopes da Fonseca, Tomás, Koch, Jan C., Becker, Stefan, Tönges, Lars, Bähr, Mathias, Outeiro, Tiago F., Zweckstetter, Markus, Lingor, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840958/
https://ncbi.nlm.nih.gov/pubmed/27101974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0310-y
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