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Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy

Spinocerebellar ataxia type 1 is one of nine polyglutamine expansion diseases and is characterized by cerebellar ataxia and neuronal degeneration in the cerebellum and brainstem. Currently, there are no effective therapies for this disease. Previously, we have shown that RNA interference mediated si...

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Publicado en:Brain
Main Authors: Keiser, Megan S., Kordower, Jeffrey H., Gonzalez-Alegre, Pedro, Davidson, Beverly L.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840549/
https://ncbi.nlm.nih.gov/pubmed/26490326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv292
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