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Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy

Spinocerebellar ataxia type 1 is one of nine polyglutamine expansion diseases and is characterized by cerebellar ataxia and neuronal degeneration in the cerebellum and brainstem. Currently, there are no effective therapies for this disease. Previously, we have shown that RNA interference mediated si...

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Detalhes bibliográficos
Publicado no:Brain
Main Authors: Keiser, Megan S., Kordower, Jeffrey H., Gonzalez-Alegre, Pedro, Davidson, Beverly L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840549/
https://ncbi.nlm.nih.gov/pubmed/26490326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv292
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