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Dietary proanthocyanidins boost hepatic NAD(+) metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats

Proanthocyanidins (PACs) have been reported to modulate multiple targets by simultaneously controlling many pivotal metabolic pathways in the liver. However, the precise mechanism of PAC action on the regulation of the genes that control hepatic metabolism remains to be clarified. Accordingly, we us...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Aragonès, Gerard, Suárez, Manuel, Ardid-Ruiz, Andrea, Vinaixa, Maria, Rodríguez, Miguel A., Correig, Xavier, Arola, Lluís, Bladé, Cinta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840337/
https://ncbi.nlm.nih.gov/pubmed/27102823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24977
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