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Dietary proanthocyanidins boost hepatic NAD(+) metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats

Proanthocyanidins (PACs) have been reported to modulate multiple targets by simultaneously controlling many pivotal metabolic pathways in the liver. However, the precise mechanism of PAC action on the regulation of the genes that control hepatic metabolism remains to be clarified. Accordingly, we us...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Aragonès, Gerard, Suárez, Manuel, Ardid-Ruiz, Andrea, Vinaixa, Maria, Rodríguez, Miguel A., Correig, Xavier, Arola, Lluís, Bladé, Cinta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840337/
https://ncbi.nlm.nih.gov/pubmed/27102823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24977
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