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Dietary proanthocyanidins boost hepatic NAD(+) metabolism and SIRT1 expression and activity in a dose-dependent manner in healthy rats

Proanthocyanidins (PACs) have been reported to modulate multiple targets by simultaneously controlling many pivotal metabolic pathways in the liver. However, the precise mechanism of PAC action on the regulation of the genes that control hepatic metabolism remains to be clarified. Accordingly, we us...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Aragonès, Gerard, Suárez, Manuel, Ardid-Ruiz, Andrea, Vinaixa, Maria, Rodríguez, Miguel A., Correig, Xavier, Arola, Lluís, Bladé, Cinta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840337/
https://ncbi.nlm.nih.gov/pubmed/27102823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24977
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