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Interaction between IGFBP7 and insulin: a theoretical and experimental study

Insulin-like growth factor binding protein 7 (IGFBP7) can bind to insulin with high affinity which inhibits the early steps of insulin action. Lack of recognition mechanism impairs our understanding of insulin regulation before it binds to insulin receptor. Here we combine computational simulations...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ruan, Wenjing, Kang, Zhengzhong, Li, Youzhao, Sun, Tianyang, Wang, Lipei, Liang, Lijun, Lai, Maode, Wu, Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840315/
https://ncbi.nlm.nih.gov/pubmed/27101796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19586
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