Interaction between IGFBP7 and insulin: a theoretical and experimental study

Insulin-like growth factor binding protein 7 (IGFBP7) can bind to insulin with high affinity which inhibits the early steps of insulin action. Lack of recognition mechanism impairs our understanding of insulin regulation before it binds to insulin receptor. Here we combine computational simulations...

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Udgivet i:Sci Rep
Main Authors: Ruan, Wenjing, Kang, Zhengzhong, Li, Youzhao, Sun, Tianyang, Wang, Lipei, Liang, Lijun, Lai, Maode, Wu, Tao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840315/
https://ncbi.nlm.nih.gov/pubmed/27101796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19586
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