An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

A nonsynonymous single-nucleotide polymorphism at codon 47 in TP53 exists in African-descent populations (P47S, rs1800371; referred to here as S47). Here we report that, in human cell lines and a mouse model, the S47 variant exhibits a modest decrease in apoptosis in response to most genotoxic stres...

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Veröffentlicht in:Genes Dev
Hauptverfasser: Jennis, Matthew, Kung, Che-Pei, Basu, Subhasree, Budina-Kolomets, Anna, Leu, Julia I-Ju, Khaku, Sakina, Scott, Jeremy P., Cai, Kathy Q., Campbell, Michelle R., Porter, Devin K., Wang, Xuting, Bell, Douglas A., Li, Xiaoxian, Garlick, David S., Liu, Qin, Hollstein, Monica, George, Donna L., Murphy, Maureen E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840298/
https://ncbi.nlm.nih.gov/pubmed/27034505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.275891.115
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