Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src

Src family tyrosine kinases (SFKs) phosphorylate caspase-8A at tyrosine (Y) 397 resulting in suppression of apoptosis. In addition, the phosphorylation of caspase-8A at other sites including Y465 has been implicated in the regulation of caspase-8 activity. However, the functional consequences of the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tsang, Jennifer LY, Jia, Song Hui, Parodo, Jean, Plant, Pamela, Lodyga, Monika, Charbonney, Emmanuel, Szaszi, Katalin, Kapus, Andras, Marshall, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839753/
https://ncbi.nlm.nih.gov/pubmed/27101103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153946
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