GEF-H1 Mediates Tumor Necrosis Factor-α-induced Rho Activation and Myosin Phosphorylation: ROLE IN THE REGULATION OF TUBULAR PARACELLULAR PERMEABILITY

Tumor necrosis factor-α (TNF-α), an inflammatory cytokine, has been shown to activate the small GTPase Rho, but the underlying signaling mechanisms remained undefined. This general problem is particularly important in the kidney, because TNF-α, a major mediator of kidney injury, is known to increase...

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Détails bibliographiques
Auteurs principaux: Kakiashvili, Eli, Speight, Pam, Waheed, Faiza, Seth, Romy, Lodyga, Monika, Tanimura, Susumu, Kohno, Michiaki, Rotstein, Ori D., Kapus, András, Szászi, Katalin
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Mechanisms of Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670151/
https://ncbi.nlm.nih.gov/pubmed/19261619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805933200
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