The Epidermal Growth Factor Receptor Mediates Tumor Necrosis Factor-α-induced Activation of the ERK/GEF-H1/RhoA Pathway in Tubular Epithelium

Tumor necrosis factor (TNF)-α induces cytoskeleton and intercellular junction remodeling in tubular epithelial cells; the underlying mechanisms, however, are incompletely explored. We have previously shown that ERK-mediated stimulation of the RhoA GDP/GTP exchange factor GEF-H1/Lfc is critical for T...

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Detalhes bibliográficos
Main Authors: Kakiashvili, Eli, Dan, Qinghong, Vandermeer, Matthew, Zhang, Yuqian, Waheed, Faiza, Pham, Monica, Szászi, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059019/
https://ncbi.nlm.nih.gov/pubmed/21212278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179903
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