Processing of human Toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes

Toll-like receptor 7 (TLR7) triggers antiviral immune responses by recognizing viral single-stranded RNA in endosomes but the biosynthetic pathway of human TLR7 (hTLR7) remains unclear. Here, we show that hTLR7 is proteolytically processed and that the C-terminal fragment selectively accumulates in...

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Udgivet i:Immunity
Main Authors: Hipp, Madeleine M., Shepherd, Dawn, Gileadi, Uzi, Aichinger, Michael C., Kessler, Benedikt M., Edelmann, Mariola J., Essalmani, Rachid, Seidah, Nabil G., Reis e Sousa, Caetano, Cerundolo, Vincenzo
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839496/
https://ncbi.nlm.nih.gov/pubmed/24138882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.09.004
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