Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels

Twik-related K(+) channel 1 (TREK1), TREK2, and Twik-related arachidonic-acid stimulated K(+) channel (TRAAK) form the TREK subfamily of two-pore-domain K(+) (K(2P)) channels. Despite sharing up to 78% sequence homology and overlapping expression profiles in the nervous system, these channels show m...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Levitz, Joshua, Royal, Perrine, Comoglio, Yannick, Wdziekonski, Brigitte, Schaub, Sébastien, Clemens, Daniel M., Isacoff, Ehud Y., Sandoz, Guillaume
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839437/
https://ncbi.nlm.nih.gov/pubmed/27035963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522459113
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