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Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid

Membrane lipids serve as second messengers and docking sites for proteins and play central roles in cell signaling. A major question about lipid signaling is whether diffusible lipids can selectively target specific proteins. One family of lipid-regulated membrane proteins is the TWIK-related K chan...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Comoglio, Yannick, Levitz, Joshua, Kienzler, Michael A., Lesage, Florian, Isacoff, Ehud Y., Sandoz, Guillaume
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169921/
https://ncbi.nlm.nih.gov/pubmed/25197053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407160111
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