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Optical control of endogenous proteins with a photo-switchable conditional subunit reveals a role for TREK1 in GABAB signaling

Selective ligands are lacking for many neuronal signaling proteins. Photoswitched tethered ligands (PTLs) have enabled fast and reversible control of specific proteins containing a PTL anchoring site and have been used to remote control over-expressed proteins. We report here a novel scheme for opti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sandoz, Guillaume, Levitz, Joshua, Kramer, Richard H., Isacoff, Ehud Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383668/
https://ncbi.nlm.nih.gov/pubmed/22726831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.04.026
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