Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival

Epidermal growth factor receptor (EGFR) and its mutant form EGFRvIII are overexpressed in a large proportion of glioblastomas (GBM). Immunotherapy with an EGFRvIII-specific vaccine has shown efficacy against GBM in clinical studies. However, immune escape by antigen-loss variants and lack of control...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Genßler, Sabrina, Burger, Michael C., Zhang, Congcong, Oelsner, Sarah, Mildenberger, Iris, Wagner, Marlies, Steinbach, Joachim P., Wels, Winfried S.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839317/
https://ncbi.nlm.nih.gov/pubmed/27141401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1119354
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