Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens

Natural killer (NK) cells can be engineered to kill resistant B-lymphoid cell lines and primary B-cell chronic lymphocytic leukemia (B-CLL) cells after transfection with chimeric antigen receptors (CARs) recognizing CD19 or CD20. Here we compared mRNA electroporation with lentiviral vector (LV) tran...

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Detalhes bibliográficos
Main Authors: Boissel, Laurent, Betancur, Monica, Lu, Weiquan, Wels, Winfried S., Marino, Teresa, Van Etten, Richard A., Klingemann, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491067/
https://ncbi.nlm.nih.gov/pubmed/22023526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10428194.2011.634048
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