Heme oxygenase-1 regulates mitochondrial quality control in the heart

The cardioprotective inducible enzyme heme oxygenase-1 (HO-1) degrades prooxidant heme into equimolar quantities of carbon monoxide, biliverdin, and iron. We hypothesized that HO-1 mediates cardiac protection, at least in part, by regulating mitochondrial quality control. We treated WT and HO-1 tran...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Hull, Travis D., Boddu, Ravindra, Guo, Lingling, Tisher, Cornelia C., Traylor, Amie M., Patel, Bindiya, Joseph, Reny, Prabhu, Sumanth D., Suliman, Hagir B., Piantadosi, Claude A., Agarwal, Anupam, George, James F.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838906/
https://ncbi.nlm.nih.gov/pubmed/27110594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85817
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