Heme oxygenase-1 regulates mitochondrial quality control in the heart

The cardioprotective inducible enzyme heme oxygenase-1 (HO-1) degrades prooxidant heme into equimolar quantities of carbon monoxide, biliverdin, and iron. We hypothesized that HO-1 mediates cardiac protection, at least in part, by regulating mitochondrial quality control. We treated WT and HO-1 tran...

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Pubblicato in:JCI Insight
Autori principali: Hull, Travis D., Boddu, Ravindra, Guo, Lingling, Tisher, Cornelia C., Traylor, Amie M., Patel, Bindiya, Joseph, Reny, Prabhu, Sumanth D., Suliman, Hagir B., Piantadosi, Claude A., Agarwal, Anupam, George, James F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838906/
https://ncbi.nlm.nih.gov/pubmed/27110594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85817
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