Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

Synthetic cell-surface glycans are promising vaccine candidates against Clostridium difficile. The complexity of large, highly antigenic and immunogenic glycans is a synthetic challenge. Less complex antigens providing similar immune responses are desirable for vaccine development. Based on molecula...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Broecker, Felix, Hanske, Jonas, Martin, Christopher E., Baek, Ju Yuel, Wahlbrink, Annette, Wojcik, Felix, Hartmann, Laura, Rademacher, Christoph, Anish, Chakkumkal, Seeberger, Peter H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838876/
https://ncbi.nlm.nih.gov/pubmed/27091615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11224
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