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Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue
The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. We built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic detail. Our results reveal that Pol II backtr...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4838855/ https://ncbi.nlm.nih.gov/pubmed/27091704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11244 |
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