Design of Peptide Substrate for Sensitively and Specifically Detecting Two Aβ-Degrading Enzymes: Neprilysin and Angiotensin-Converting Enzyme

Upregulation of neprilysin (NEP) to reduce Aβ accumulation in the brain is a promising strategy for the prevention of Alzheimer’s disease (AD). This report describes the design and synthesis of a quenched fluorogenic peptide substrate qf-Aβ(12–16)AAC (with the sequence VHHQKAAC), which has a fluorop...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chen, Po-Ting, Chen, Chao-Long, Lin, Lilian Tsai-Wei, Lo, Chun-Hsien, Hu, Chaur-Jong, Chen, Rita P.-Y., Wang, Steven S.-S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838334/
https://ncbi.nlm.nih.gov/pubmed/27096746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153360
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