Two FGFR kinase molecules act in concert to recruit and transphosphorylate PLCγ

The molecular basis by which receptor tyrosine kinases (RTKs) recruit and phosphorylate Src Homology 2 (SH2) domain-containing substrates has remained elusive. We used X-ray crystallography, NMR spectroscopy, and cell-based assays to demonstrate that recruitment and phosphorylation of Phospholipase...

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Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Huang, Zhifeng, Marsiglia, William M., BasuRoy, Upal, Rahimi, Nader, Ilghari, Dariush, Wang, Huiyan, Chen, Huaibin, Gai, Weiming, Blais, Steven, Neubert, Thomas A., Mansukhani, Alka, Traaseth, Nathaniel J., Li, Xiaokun, Mohammadi, Moosa
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838190/
https://ncbi.nlm.nih.gov/pubmed/26687682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.11.010
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