A phase Ia/Ib clinical trial of metronomic chemotherapy based on a mathematical model of oral vinorelbine in metastatic non-small cell lung cancer and malignant pleural mesothelioma: rationale and study protocol

BACKGROUND: Metronomic oral vinorelbine is effective in metastatic NSCLC and malignant pleural mesothelioma, but all the studies published thus far were based upon a variety of empirical and possibly suboptimal schedules, with inconsistent results. Mathematical modelling showed by simulation that a...

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Publicat a:BMC Cancer
Autors principals: Elharrar, Xavier, Barbolosi, Dominique, Ciccolini, Joseph, Meille, Christophe, Faivre, Christian, Lacarelle, Bruno, André, Nicolas, Barlesi, Fabrice
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Study Protocol
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837593/
https://ncbi.nlm.nih.gov/pubmed/27094927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2308-z
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