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The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Many transformed cells exhibit altered glucose metabolism and increased utilization of glutamine for anabolic and bioenergetic processes. These metabolic adaptations, which accompany tumorigenesis, are driven by oncogenic signals. Here we report that the transcription factor c-Jun, product of the pr...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Lukey, Michael J., Greene, Kai Su, Erickson, Jon W., Wilson, Kristin F., Cerione, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837472/
https://ncbi.nlm.nih.gov/pubmed/27089238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11321
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