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The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy

Many transformed cells exhibit altered glucose metabolism and increased utilization of glutamine for anabolic and bioenergetic processes. These metabolic adaptations, which accompany tumorigenesis, are driven by oncogenic signals. Here we report that the transcription factor c-Jun, product of the pr...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Lukey, Michael J., Greene, Kai Su, Erickson, Jon W., Wilson, Kristin F., Cerione, Richard A.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837472/
https://ncbi.nlm.nih.gov/pubmed/27089238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11321
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