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The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: a role for the NLRP3 inflammasome

The alarmin high mobility group box-1 (HMGB1) has been implicated as a key factor mediating neuroinflammatory processes. Recent findings suggest that the redox state of HMGB1 is a critical molecular feature of HMGB1 such that the reduced form (fr-HMGB1) is chemotactic, while the disulfide form (ds-H...

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Udgivet i:Brain Behav Immun
Main Authors: Frank, Matthew G., Weber, Michael D., Fonken, Laura K., Hershman, Sarah A., Watkins, Linda R., Maier, Steven F.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837097/
https://ncbi.nlm.nih.gov/pubmed/26482581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2015.10.009
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