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miR-186 is decreased in aged brain and suppresses BACE1 expression

Accumulation of amyloid β (Aβ) in the brain is a key pathological hallmark of Alzheimer’s disease (AD). Because aging is the most prominent risk factor for AD, understanding the molecular changes during aging is likely to provide critical insights into AD pathogenesis. However, studies on the role o...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Kim, Jaekwang, Yoon, Hyejin, Chung, Dah-eun, Brown, Jennifer L., Belmonte, Krystal C., Kim, Jungsu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837067/
https://ncbi.nlm.nih.gov/pubmed/26710318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13507
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