DNA polymerase-α regulates type I interferon activation through cytosolic RNA:DNA synthesis

Aberrant nucleic acids generated during viral replication are the main trigger for antiviral immunity, and mutations disrupting nucleic acid metabolism can lead to autoinflammatory disorders. Here we investigated the etiology of X-linked reticulate pigmentary disorder (XLPDR), a primary immunodefici...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Immunol
Main Authors: Starokadomskyy, Petro, Gemelli, Terry, Rios, Jonathan J., Xing, Chao, Wang, Richard C., Li, Haiying, Pokatayev, Vladislav, Dozmorov, Igor, Khan, Shaheen, Miyata, Naoteru, Fraile, Guadalupe, Raj, Prithvi, Xu, Zhe, Xu, Zigang, Ma, Lin, Lin, Zhimiao, Wang, Huijun, Yang, Yong, Ben-Amitai, Dan, Orenstein, Naama, Mussaffi, Huda, Baselga, Eulalia, Tadini, Gianluca, Grunebaum, Eyal, Sarajlija, Adrijan, Krzewski, Konrad, Wakeland, Edward K., Yan, Nan, de la Morena, Maria Teresa, Zinn, Andrew R., Burstein, Ezra
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836962/
https://ncbi.nlm.nih.gov/pubmed/27019227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3409
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