DNA polymerase-α regulates type I interferon activation through cytosolic RNA:DNA synthesis

Aberrant nucleic acids generated during viral replication are the main trigger for antiviral immunity, and mutations disrupting nucleic acid metabolism can lead to autoinflammatory disorders. Here we investigated the etiology of X-linked reticulate pigmentary disorder (XLPDR), a primary immunodefici...

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Bibliografski detalji
Izdano u:Nat Immunol
Glavni autori: Starokadomskyy, Petro, Gemelli, Terry, Rios, Jonathan J., Xing, Chao, Wang, Richard C., Li, Haiying, Pokatayev, Vladislav, Dozmorov, Igor, Khan, Shaheen, Miyata, Naoteru, Fraile, Guadalupe, Raj, Prithvi, Xu, Zhe, Xu, Zigang, Ma, Lin, Lin, Zhimiao, Wang, Huijun, Yang, Yong, Ben-Amitai, Dan, Orenstein, Naama, Mussaffi, Huda, Baselga, Eulalia, Tadini, Gianluca, Grunebaum, Eyal, Sarajlija, Adrijan, Krzewski, Konrad, Wakeland, Edward K., Yan, Nan, de la Morena, Maria Teresa, Zinn, Andrew R., Burstein, Ezra
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836962/
https://ncbi.nlm.nih.gov/pubmed/27019227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3409
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