Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

[Image: see text] Bioisosteric replacements are widely used in medicinal chemistry to improve physicochemical and ADME properties of molecules while retaining or improving affinity. Here, using the p53 cancer mutant Y220C as a test case, we investigate both computationally and experimentally whether...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Chem Biol
Main Authors: Wilcken, Rainer, Zimmermann, Markus O., Bauer, Matthias R., Rutherford, Trevor J., Fersht, Alan R., Joerger, Andreas C., Boeckler, Frank M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836799/
https://ncbi.nlm.nih.gov/pubmed/26378745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00515
Oznake: Označite
Brez oznak, prvi označite!
Nalaganje...

Podobne knjige/članki