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Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere
[Image: see text] Bioisosteric replacements are widely used in medicinal chemistry to improve physicochemical and ADME properties of molecules while retaining or improving affinity. Here, using the p53 cancer mutant Y220C as a test case, we investigate both computationally and experimentally whether...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2015
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4836799/ https://ncbi.nlm.nih.gov/pubmed/26378745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00515 |
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