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Critical Role of Autophagy in the Processing of Adenovirus Capsid-Incorporated Cancer-Specific Antigens

Adenoviruses are highly immunogenic and are being examined as potential vectors for immunotherapy. Infection by oncolytic adenovirus is followed by massive autophagy in cancer cells. Here, we hypothesize that autophagy regulates the processing of adenoviral proteins for antigen presentation. To test...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Klein, Sarah R., Jiang, Hong, Hossain, Mohammad B., Fan, Xuejun, Gumin, Joy, Dong, Andrew, Alonso, Marta M., Gomez-Manzano, Candelaria, Fueyo, Juan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836716/
https://ncbi.nlm.nih.gov/pubmed/27093696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153814
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