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Critical Role of Autophagy in the Processing of Adenovirus Capsid-Incorporated Cancer-Specific Antigens

Adenoviruses are highly immunogenic and are being examined as potential vectors for immunotherapy. Infection by oncolytic adenovirus is followed by massive autophagy in cancer cells. Here, we hypothesize that autophagy regulates the processing of adenoviral proteins for antigen presentation. To test...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Klein, Sarah R., Jiang, Hong, Hossain, Mohammad B., Fan, Xuejun, Gumin, Joy, Dong, Andrew, Alonso, Marta M., Gomez-Manzano, Candelaria, Fueyo, Juan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836716/
https://ncbi.nlm.nih.gov/pubmed/27093696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153814
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