Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo

Tumor-associated macrophages (TAMs) represent an important cellular subset within the glioblastoma (WHO grade IV) microenvironment and are a potential therapeutic target. TAMs display a continuum of different polarization states between antitumorigenic M1 and protumorigenic M2 phenotypes, with a low...

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Udgivet i:PLoS One
Main Authors: Zhang, Michael, Hutter, Gregor, Kahn, Suzana A., Azad, Tej D., Gholamin, Sharareh, Xu, Chelsea Y., Liu, Jie, Achrol, Achal S., Richard, Chase, Sommerkamp, Pia, Schoen, Matthew Kenneth, McCracken, Melissa N., Majeti, Ravi, Weissman, Irving, Mitra, Siddhartha S., Cheshier, Samuel H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836698/
https://ncbi.nlm.nih.gov/pubmed/27092773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153550
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