CS-07 mTORC2/Akt SIGNALING IS MODULATED BY NONCANONICAL MITOCHONDRIAL NOTCH-PINK1 INTERACTION IN MEDULLOBLASTOMA (GROUP III) TUMORIGENESIS

MYC-amplified medulloblastoma is a lethal pediatric tumor lacking effective treatment options. Targeting of mitochondrial activity through inhibition of a novel, noncanonical Notch/PINK1 signaling pathway was recently shown to attenuate the viability of human glioblastoma as performed by our laborat...

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Main Authors: Feroze, Abdullah, Lee, Kyu-Sun, Alrfaei, Bahauddeen, Gholamin, Sharareh, Azad, Tej, Mitra, Siddhartha, Lu, Bingwei, Cheshier, Samuel
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218000/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou242.7
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