Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein

Assembly of HIV-1 particles is initiated by the trafficking of viral Gag polyproteins from the cytoplasm to the plasma membrane (PM), where they co-localize and bud to form immature particles. Membrane targeting is mediated by the N-terminally myristoylated matrix (MA) domain of Gag and is dependent...

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Udgivet i:J Mol Biol
Main Authors: Mercredi, Peter Y., Bucca, Nadine, Loeliger, Burk, Gaines, Christy R., Mehta, Mansi, Bhargava, Pallavi, Tedbury, Philip R., Charlier, Landry, Floquet, Nicolas, Muriaux, Delphine, Favard, Cyril, Sanders, Charles R., Freed, Eric O., Marchant, Jan, Summers, Michael F.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836608/
https://ncbi.nlm.nih.gov/pubmed/26992353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.03.005
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