A Simplified Method for Quantifying Sulfur Mustard Adducts to Blood Proteins by Ultra-High Pressure Liquid Chromatography-Isotope Dilution Tandem Mass Spectrometry

Sulfur mustard binds to reactive cysteine residues, forming a stable sulfur-hydroxyethylthioethyl [S-HETE] adduct that can be used as a long-term biomarker of sulfur mustard exposure in humans. The digestion of sulfur mustard-exposed blood samples with proteinase K following total protein precipitat...

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Publié dans:Chem Res Toxicol
Auteurs principaux: Pantazides, Brooke G., Crow, Brian S., Garton, Joshua W., Quiñones-González, Jennifer A., Blake, Thomas A., Thomas, Jerry D., Johnson, Rudolph C.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836402/
https://ncbi.nlm.nih.gov/pubmed/25622494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500468h
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