Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses

One of the challenges of developing influenza A vaccines is the diversity of antigenically distinct isolates. Previously, a novel hemagglutinin (HA) for H5N1 influenza was derived from a methodology termed computationally optimized broadly reactive antigen (COBRA). This COBRA HA elicited a broad ant...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Carter, Donald M., Darby, Christopher A., Lefoley, Bradford C., Crevar, Corey J., Alefantis, Timothy, Oomen, Raymond, Anderson, Stephen F., Strugnell, Tod, Cortés-Garcia, Guadalupe, Vogel, Thorsten U., Parrington, Mark, Kleanthous, Harold, Ross, Ted M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2016
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836330/
https://ncbi.nlm.nih.gov/pubmed/26912624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03152-15
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