A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection

BACKGROUND: Highly pathogenic H5N1 avian influenza viruses continue to spread via waterfowl, causing lethal infections in humans. Vaccines can prevent the morbidity and mortality associated with pandemic influenza isolates. Predicting the specific isolate that may emerge from the 10 different H5N1 c...

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Bibliographic Details
Main Authors: Giles, Brendan M., Crevar, Corey J., Carter, Donald M., Bissel, Stephanie J., Schultz-Cherry, Stacey, Wiley, Clayton A., Ross, Ted M.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Major Articles and Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415819/
https://ncbi.nlm.nih.gov/pubmed/22448011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis232
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