A Computationally Optimized Hemagglutinin Virus-Like Particle Vaccine Elicits Broadly Reactive Antibodies that Protect Nonhuman Primates from H5N1 Infection

BACKGROUND: Highly pathogenic H5N1 avian influenza viruses continue to spread via waterfowl, causing lethal infections in humans. Vaccines can prevent the morbidity and mortality associated with pandemic influenza isolates. Predicting the specific isolate that may emerge from the 10 different H5N1 c...

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Hlavní autoři: Giles, Brendan M., Crevar, Corey J., Carter, Donald M., Bissel, Stephanie J., Schultz-Cherry, Stacey, Wiley, Clayton A., Ross, Ted M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415819/
https://ncbi.nlm.nih.gov/pubmed/22448011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis232
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