Antibody Breadth and Protective Efficacy Are Increased by Vaccination with Computationally Optimized Hemagglutinin but Not with Polyvalent Hemagglutinin-Based H5N1 Virus-Like Particle Vaccines

One of the challenges for developing an H5N1 influenza vaccine is the diversity of antigenically distinct isolates within this subtype. Previously, our group described a novel hemagglutinin (HA) derived from a methodology termed computationally optimized broadly reactive antigen (COBRA). This COBRA...

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Hlavní autoři: Giles, Brendan M., Bissel, Stephanie J., DeAlmeida, Dilhari R., Wiley, Clayton A., Ross, Ted M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272934/
https://ncbi.nlm.nih.gov/pubmed/22190399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05533-11
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