Computer-Aided Design of Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5): Comparative Molecular Field Analysis of Aryl Ether Derivatives

The metabotropic glutamate receptors (mGlu receptors) have emerged as attractive targets for number of neurological and psychiatric disorders. Recently, mGluR5 negative allosteric modulators (NAMs) have gained considerable attention in pharmacological research. Comparative Molecular Field Analysis (...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Selvam, Chelliah, Thilagavathi, Ramasamy, Narasimhan, Balasubramanian, Kumar, Pradeep, Jordan, Brian C, Ranganna, Kasturi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836281/
https://ncbi.nlm.nih.gov/pubmed/26826734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.01.051
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