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Computer-Aided Design of Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (mGluR5): Comparative Molecular Field Analysis of Aryl Ether Derivatives

The metabotropic glutamate receptors (mGlu receptors) have emerged as attractive targets for number of neurological and psychiatric disorders. Recently, mGluR5 negative allosteric modulators (NAMs) have gained considerable attention in pharmacological research. Comparative Molecular Field Analysis (...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Selvam, Chelliah, Thilagavathi, Ramasamy, Narasimhan, Balasubramanian, Kumar, Pradeep, Jordan, Brian C, Ranganna, Kasturi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836281/
https://ncbi.nlm.nih.gov/pubmed/26826734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.01.051
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