Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson’s disease (PD)

Mutations of F-box protein 7 (FBXO7) and Parkin, two proteins in ubiquitin-proteasome system (UPS), are both implicated in pathogenesis of dopamine (DA) neuron degeneration in Parkinson’s disease (PD). Parkin is a HECT/RING hybrid ligase that physically receives ubiquitin on its catalytic centre and...

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Udgivet i:Mol Brain
Main Authors: Zhou, Zhi Dong, Sathiyamoorthy, Sushmitha, Angeles, Dario C., Tan, Eng King
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835861/
https://ncbi.nlm.nih.gov/pubmed/27090516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0218-2
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