Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications.

The importance of the 2'-hydroxyl group of several guanosine residues for the catalytic efficiency of a hammerhead ribozyme has been investigated. Five ribozymes in which single guanosine residues were substituted with 2'-amino-, 2'-fluoro-, or 2'-deoxyguanosine were chemically synthesized. The comp...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Williams, D M, Pieken, W A, Eckstein, F
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1992
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48356/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1736306/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.3.918
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