Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Huntington’s disease is an autosomal-dominant neurodegenerative disorder, with chorea as the most prominent manifestation. The disease is caused by abnormal expansion of CAG codon repeats in the IT15 gene, which leads to the expression of a glutamine-rich protein named mutant Huntingtin (Htt). Becau...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Zeng, Yixuan, Guo, Wenyuan, Xu, Guangqing, Wang, Qinmei, Feng, Luyang, Long, Simei, Liang, Fengyin, Huang, Yi, Lu, Xilin, Li, Shichang, Zhou, Jiebin, Burgunder, Jean-Marc, Pang, Jiyan, Pei, Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835117/
https://ncbi.nlm.nih.gov/pubmed/27110099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S94666
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