Xyloketal-derived small molecules show protective effect by decreasing mutant Huntingtin protein aggregates in Caenorhabditis elegans model of Huntington’s disease

Huntington’s disease is an autosomal-dominant neurodegenerative disorder, with chorea as the most prominent manifestation. The disease is caused by abnormal expansion of CAG codon repeats in the IT15 gene, which leads to the expression of a glutamine-rich protein named mutant Huntingtin (Htt). Becau...

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Publicado en:Drug Des Devel Ther
Autores principales: Zeng, Yixuan, Guo, Wenyuan, Xu, Guangqing, Wang, Qinmei, Feng, Luyang, Long, Simei, Liang, Fengyin, Huang, Yi, Lu, Xilin, Li, Shichang, Zhou, Jiebin, Burgunder, Jean-Marc, Pang, Jiyan, Pei, Zhong
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2016
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835117/
https://ncbi.nlm.nih.gov/pubmed/27110099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S94666
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