Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus

Significant genetic variability in the head region of the influenza A hemagglutinin, the main target of current vaccines, makes it challenging to develop a long-lived seasonal influenza prophylaxis. Vaccines based on the conserved hemagglutinin stalk domain might provide broader cross-reactive immun...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Klausberger, Miriam, Tscheliessnig, Rupert, Neff, Silke, Nachbagauer, Raffael, Wohlbold, Teddy John, Wilde, Monika, Palmberger, Dieter, Krammer, Florian, Jungbauer, Alois, Grabherr, Reingard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835069/
https://ncbi.nlm.nih.gov/pubmed/27088239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153579
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